Blastoma

Many modern cancer drugs target a specific genetic mutation that is driving a particular cancer's runaway growth and division -- such as the HER-2 protein in some breast cancers or EGFR in certain lung cancers. But this strategy hasn't worked well against glioblastoma, an aggressive form of brain cancer, which…

IMAGE: A) Arsenic Trioxide (ATO) reduces the clonogenic capacity of medulloblastoma (MB) cell lines of the SHH subgroup (DAOY: TP53 c.725G>T; UW402: TP53 c.464C>A and ONS-76: TP53 wild type). B) Clonogenic... view more  Credit: Paulo Henrique dos Santos Klinger By André Julião | Agência FAPESP – Researchers affiliated with the University…

AbstractCell division and organismal development are exquisitely orchestrated and regulated processes. The dysregulation of the molecular mechanisms underlying these processes may cause cancer, a consequence of cell-intrinsic and/or cell-extrinsic events. Cellular DNA can be damaged by spontaneous hydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DNA…

Loading metrics Open Access Peer-reviewed Research Article Melissa F. Adasme , Daniele Parisi , Kristien Van Belle, Sebastian Salentin, V. Joachim Haupt, Gary S. Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder Melissa F. Adasme,  Daniele Parisi,  Kristien Van Belle,  Sebastian Salentin,  V. Joachim Haupt, …

Loading metrics Open Access Peer-reviewed Research Article Tomoya Kitakaze,  Atsushi Makiyama,  Yoko Yamashita,  Hitoshi Ashida x Published: April 9, 2020 https://doi.org/10.1371/journal.pone.0231403 AbstractA flavone luteolin has various health-promoting activities. Several studies reported that high dose of luteolin activates the Nrf2/ARE pathway in the liver. However, the effect of the low dose…

YORK, Pa. – Eve and Ella Oakley’s wish has come  true. The twins are on vacation in Florida.They’re taking a break from the hospitals and tests and therapies in their battle with cancer, a war they’ve waged since they were born two years ago.And it isn’t the only battle they’ve endured.“Literally, the…

Kim Strong York Daily RecordPublished 2:28 PM EDT Mar 8, 2020YORK, Pa. – Eve and Ella Oakley’s wish has come  true. The twins are on vacation in Florida.They’re taking a break from the hospitals and tests and therapies in their battle with cancer, a war they’ve waged since they were born two…

1.Korshunov, A. et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol. 128, 279289 (2014).

1.Korshunov, A. et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol. 128, 279289 (2014).

It was back in November 2015 when Lynsay Hughes and her husband Andrew, a project engineer, both 38, first noticed their two-year-old Evie was out of sorts. Wed begun potty training and it was going really well, but Evie suddenly started refusing to go to t…