Blastoma

Summary: A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed. In vivo experiments demonstrated that the combined use of epirubicin-encapsulating nano-micelles (Epi/m) with immune checkpoint inhibitors (ICI) eradicated PTEN-negative GBM, which is highly resistant to ICI alone. Due to…

IMAGE: TLK inhibition show replication intermediates (green) at chromosome ends (red) view more  Credit: (IRB Barcelona) Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona's Genomic Instability and Cancer Laboratory, led by Travis…

Many modern cancer drugs target a specific genetic mutation that is driving a particular cancer's runaway growth and division -- such as the HER-2 protein in some breast cancers or EGFR in certain lung cancers. But this strategy hasn't worked well against glioblastoma, an aggressive form of brain cancer, which…

IMAGE: A) Arsenic Trioxide (ATO) reduces the clonogenic capacity of medulloblastoma (MB) cell lines of the SHH subgroup (DAOY: TP53 c.725G>T; UW402: TP53 c.464C>A and ONS-76: TP53 wild type). B) Clonogenic... view more  Credit: Paulo Henrique dos Santos Klinger By André Julião | Agência FAPESP – Researchers affiliated with the University…

AbstractCell division and organismal development are exquisitely orchestrated and regulated processes. The dysregulation of the molecular mechanisms underlying these processes may cause cancer, a consequence of cell-intrinsic and/or cell-extrinsic events. Cellular DNA can be damaged by spontaneous hydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DNA…

Loading metrics Open Access Peer-reviewed Research Article Melissa F. Adasme , Daniele Parisi , Kristien Van Belle, Sebastian Salentin, V. Joachim Haupt, Gary S. Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder Melissa F. Adasme,  Daniele Parisi,  Kristien Van Belle,  Sebastian Salentin,  V. Joachim Haupt, …

Loading metrics Open Access Peer-reviewed Research Article Tomoya Kitakaze,  Atsushi Makiyama,  Yoko Yamashita,  Hitoshi Ashida x Published: April 9, 2020 https://doi.org/10.1371/journal.pone.0231403 AbstractA flavone luteolin has various health-promoting activities. Several studies reported that high dose of luteolin activates the Nrf2/ARE pathway in the liver. However, the effect of the low dose…

YORK, Pa. – Eve and Ella Oakley’s wish has come  true. The twins are on vacation in Florida.They’re taking a break from the hospitals and tests and therapies in their battle with cancer, a war they’ve waged since they were born two years ago.And it isn’t the only battle they’ve endured.“Literally, the…

Kim Strong York Daily RecordPublished 2:28 PM EDT Mar 8, 2020YORK, Pa. – Eve and Ella Oakley’s wish has come  true. The twins are on vacation in Florida.They’re taking a break from the hospitals and tests and therapies in their battle with cancer, a war they’ve waged since they were born two…

1.Korshunov, A. et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol. 128, 279289 (2014).