Category

Blastoma

Blastoma

Epirubicin-loaded nanomedicines beat immune checkpoint blockade resistance in glioblastoma

Summary: A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed. In vivo experiments demonstrated that the combined use of epirubicin-encapsulating nano-micelles (Epi/m) with immune checkpoint inhibitors (ICI) eradicated PTEN-negative GBM, which is highly resistant to ICI alone. Due to…
bubmag
August 7, 2020
Blastoma

TLK protein inhibition activates the innate immune system

IMAGE: TLK inhibition show replication intermediates (green) at chromosome ends (red) view more  Credit: (IRB Barcelona) Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona's Genomic Instability and Cancer Laboratory, led by Travis…
bubmag
August 5, 2020
Blastoma

Tumour predisposition and cancer syndromes as models to study gene–environment interactions

AbstractCell division and organismal development are exquisitely orchestrated and regulated processes. The dysregulation of the molecular mechanisms underlying these processes may cause cancer, a consequence of cell-intrinsic and/or cell-extrinsic events. Cellular DNA can be damaged by spontaneous hydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DNA…
bubmag
May 29, 2020
Blastoma

Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor

Loading metrics Open Access Peer-reviewed Research Article Melissa F. Adasme , Daniele Parisi , Kristien Van Belle, Sebastian Salentin, V. Joachim Haupt, Gary S. Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder Melissa F. Adasme,  Daniele Parisi,  Kristien Van Belle,  Sebastian Salentin,  V. Joachim Haupt, …
bubmag
May 27, 2020
Blastoma

Low dose of luteolin activates Nrf2 in the liver of mice at start of the active phase but not that of the inactive phase

Loading metrics Open Access Peer-reviewed Research Article Tomoya Kitakaze,  Atsushi Makiyama,  Yoko Yamashita,  Hitoshi Ashida x Published: April 9, 2020 https://doi.org/10.1371/journal.pone.0231403 AbstractA flavone luteolin has various health-promoting activities. Several studies reported that high dose of luteolin activates the Nrf2/ARE pathway in the liver. However, the effect of the low dose…
bubmag
April 9, 2020