Blastoma

A recent clinical trial took a different approach to treating glioblastoma, with signs of extended survival. (Image credit: DR P. MARAZZI/SCIENCE PHOTO LIBRARY via Getty Images) A new therapy for the most aggressive type of brain cancer can extend patients' survival while cutting the length of treatment. The cancer, glioblastoma…

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a promising new approach for treating glioblastoma, an aggressive and lethal type of brain cancer. The team of researchers discovered that endocan, which is produced by endothelial cells lining blood…

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Proceedings of the National Academy of Sciences, Volume 121, Issue 52, December 2024. SignificanceSonic hedgehog (SHH) promotes proliferation of granule cell (GC) progenitors in the postnatal cerebellum and in the pediatric tumor, medulloblastoma, through specialized compartments called primary cilia. During neuronal maturation, GCs stop ...Read More

Research from Washington University shows that glioblastoma, a type of brain cancer, has its own internal clock that synchronizes with the host’s circadian rhythms to optimize its growth by responding to daily hormone releases like cortisol. Targeting these circadian signals in treatment slowed tumor growth significantly in both lab and…

Europe’s Committee for Medicinal Products for Human Use (CHMP) has recommended refusal of marketing authorizations for: Cinainu (allium/citrus/Paullinia/cacao), an herbal medicine intended to treat moderate to severe alopecia areata in children and adolescents Kizfizo (temozolomide) for the treatment of neuroblastoma in children older than 1 year Herbal Extracts Cinainu contains…

MRI scan of 72-year-old glioblastoma patient. (Choi et al., NEMJ, 2024) Brain scans of a 72-year-old man diagnosed with a highly aggressive form of cancer known as a glioblastoma have revealed a remarkable regression in his tumor's size within days of receiving an infusion of an innovative new treatment. Though…

Glioblastomas are the most aggressive form of brain cancer. An example of one of these tumors is shown in the colored brain scan image above in orange. (Image credit: DR P. MARAZZI/SCIENCE PHOTO LIBRARY via Getty Images) A new immune cell-based treatment for glioblastoma , the most aggressive type of…

The US Food and Drug Administration (FDA) approved eflornithine (Iwilfin) to reduce the risk for relapse in patients with high-risk neuroblastoma who have demonstrated at least a partial response to prior multiagent, multimodality therapy, including anti-GD2 immunotherapy.  This approval is the first of a therapy intended to reduce the risk…

TV presenter Annabel Giles dies after being diagnosed with 'highly aggressive' brain tumour The actress underwent 'countless radiotherapies' since being diagnosed with stage four Glioblastoma in July Television presenter and actress Annabel Giles has died, aged 64, after being diagnosed with a brain tumour in July, her children said in…