Blastoma

A YOUNG mum who is battling terminal brain cancer says the upcoming EastEnders episode featuring Lola Pearce-Brown’s funeral will be ‘too hard’ to watch. Laura Mahon, 31, from St Helens, Merseyside, knows one day her family will have to go through the same heartache. 7 Laura Mahon was pregnant when…

John Wishman was diagnosed with the deadliest form of brain cancer, glioblastoma, in fall 2020. Two and a half years later, he’s still traveling and enjoying life — a rarity for a cancer with an average survival time of just 12 to 18 months.  Wishman, 61, of Buffalo, New York,…

A new “miracle” gel shows great promise for brain tumour treatment during lab tests at Johns Hopkins University. The gel is used to treat one of the most aggressive forms of brain tumour, glioblastoma, leaving patients with a diagnosed life expectancy of 12 – 18 months. The new treatment is…

The combination of oncolytic DNX-2401 virotherapy with pembrolizumab (Keytruda) failed to meet a phase I/II study's primary endpoint of objective response rate (ORR) in patients with recurrent glioblastoma, but did demonstrate a "notable survival benefit" in select patients. Among 49 patients who received DNX-2401 followed by pembrolizumab, the ORR was…

TORONTO – A new international study published in Nature Medicine and presented as a late-breaking abstract at the American Association of Neurological Surgeons (AANS) annual conference, shows great promise for patients with glioblastoma. Drs. Farshad Nassiri and Gelareh Zadeh, neurosurgeons at the University Health Network (UHN) in Toronto, published the…

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Chemotherapy is a cancer treatment that uses drugs to destroy cancer cells in the body. However, one of the biggest challenges of chemotherapy is getting the drugs to reach the cancer cells in the brain. This is because the blood-brain barrier, which separates the blood vessels in the brain from…

Use of a novel skull-implantable ultrasound device was able to open the blood-brain barrier, which allowed for penetration of albumin-bound paclitaxel into critical regions of the brain in patients with glioblastoma, a dose-escalation phase I trial showed. Looking at low-intensity pulsed ultrasound with concomitant administration of intravenous microbubbles (LIPU-MB) with…

Health Penetrating the blood-brain barrier via pulses of ultrasound waves led to a three-fold increase in the concentration of a chemotherapy drug in people with the brain cancer glioblastoma multiforme By Soumya Sagar The blood-brain barrier acts as a roadblock against toxic substances and microorganisms CAROL & MIKE WERNER/SCIENCE PHOTO…

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