Blastoma

The combination of oncolytic DNX-2401 virotherapy with pembrolizumab (Keytruda) failed to meet a phase I/II study's primary endpoint of objective response rate (ORR) in patients with recurrent glioblastoma, but did demonstrate a "notable survival benefit" in select patients. Among 49 patients who received DNX-2401 followed by pembrolizumab, the ORR was…

TORONTO – A new international study published in Nature Medicine and presented as a late-breaking abstract at the American Association of Neurological Surgeons (AANS) annual conference, shows great promise for patients with glioblastoma. Drs. Farshad Nassiri and Gelareh Zadeh, neurosurgeons at the University Health Network (UHN) in Toronto, published the…

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Chemotherapy is a cancer treatment that uses drugs to destroy cancer cells in the body. However, one of the biggest challenges of chemotherapy is getting the drugs to reach the cancer cells in the brain. This is because the blood-brain barrier, which separates the blood vessels in the brain from…

Use of a novel skull-implantable ultrasound device was able to open the blood-brain barrier, which allowed for penetration of albumin-bound paclitaxel into critical regions of the brain in patients with glioblastoma, a dose-escalation phase I trial showed. Looking at low-intensity pulsed ultrasound with concomitant administration of intravenous microbubbles (LIPU-MB) with…

Health Penetrating the blood-brain barrier via pulses of ultrasound waves led to a three-fold increase in the concentration of a chemotherapy drug in people with the brain cancer glioblastoma multiforme By Soumya Sagar The blood-brain barrier acts as a roadblock against toxic substances and microorganisms CAROL & MIKE WERNER/SCIENCE PHOTO…

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CUT AND RUN Published: 0:54, 21 Apr 2023A WOMAN who dumped her boyfriend because he had cancer is now running the London Marathon in his honour. Danielle Epstein, 32, said she ''felt like the most awful person" after leaving ex Jelle Fresen when he was diagnosed. 3 Danielle Epstein, 32,…

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Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better…