Antibiotics

Researchers have successfully replaced a section of the antibiotic-synthesizing enzyme PikAIII-M5, advancing our understanding of its structure and function and moving us closer to the creation of synthetic antibiotics. Credit: Tohoku University Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely…

Researchers found that a common antibiotic-resistant bacterium prevents wounds from healing by chemically paralyzing skin cells rather than attacking them directly. Scientists from an international research group led by Nanyang Technological University, Singapore (NTU Singapore), have identified an approach that may help chronic wounds heal faster...Read More

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. SignificanceThe bacterium that causes tuberculosis,Mycobacterium tuberculosis, is inherently resistant to many antibiotics. The mechanisms that mediate this resistance are not yet fully understood. Here, we identify a protein, here named TapA, that is ...Read More

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. SignificanceTreatment options for life-threatening kidney and intestinal diseases caused by EnterohemorrhagicEscherichia coli(EHEC)—affecting 265,000 people, especially children, per annum in the United States—are limited as antibiotics are ...Read More

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. SignificanceAntibiotic failure is a major clinical problem that cannot always be explained by traditional resistance mechanisms. This study reveals that the host immune protein calprotectin, which is abundant at infection sites, can interfere with β...Read More

Scientists identified a promising antibiotic active ingredient, and it contains the metal iridium (pictured above). (Image credit: RHJ/Getty Images) An iridium metal complex has been identified as a promising, if unconventional, new antibiotic drug, a new study finds. The compound is one of more than 600 produced in a study…

Planning some international travel as one of your New Year's resolutions? Then be forewarned: Travelers' diarrhea is becoming harder to treat. The antibiotics typically used to treat travelers' diarrhea are becoming less effective, researchers recently reported in JAMA Network Open. Specifically, the bacteria that cause the illness are showing increased…

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Around a decade ago, the US implemented new rules to limit the widespread use of antibiotics in meat and dairy production, in an effort to combat the nation’s antibiotic resistance crisis. The regulations helped: Antibiotic sales for use on farms plunged by 43 percent from 2015 to 2017, and plateaued…

Neisseria gonorrhoeae bacteria J Marshall/Tribaleye Images / Alamy Drug-resistant gonorrhoea is on the rise worldwide, but a new antibiotic could buy us more time before the emergence of completely untreatable strains of the bacteria, which is known to potentially raise the risk of infertility. The sexually transmitted infection is estimated…