Category

Antibiotics

Photosynthesis in a droplet Antibiotics

Photosynthesis in a droplet

For hundreds of millions of years plants have had the ability to harness carbon dioxide from the air using solar energy. The Max Planck research network MaxSynBio is on the trail of building artificial cells as sustainable green bioreactors. A Max Planck research team led by Tobias Erb from the…
bubmag
May 11, 2020
Sepsis in Children Antibiotics

Sepsis in Children

Sepsis may not be on your radar but it is an extremely deadly killer. Worldwide, a stunning one-third of people who get it die, and many who do live have life-changing side effects such as chronic pain and fatigue, organs that don’t work well, even amputations. Sepsis is caused by…
bubmag
May 11, 2020
Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics Antibiotics

Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics

Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics† Author affiliations * Corresponding authors a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK E-mail: chris.willis@bristol.ac.uk, matt.crump@bristol.ac.uk b School of Biochemistry, University of Bristol, University Walk, Bristol, UK c School of Cellular…
bubmag
May 9, 2020
Why Are There So Many Drugs To Kill Bacteria, But So Few To Tackle Viruses? Antibiotics

Why Are There So Many Drugs To Kill Bacteria, But So Few To Tackle Viruses?

Image: Getty Images As the end of the second world war neared, mass production of the newly developed antibiotic penicillin enabled life-saving treatment of bacterial infections in wounded soldiers. Since then, penicillin and many other antibiotics have successfully treated a wide variety of bacterial infections. But antibiotics don’t work against…
bubmag
May 8, 2020
[ASAP] Sugar-Pirating as an Enabling Platform for the Synthesis of 4,6-Dideoxyhexoses Antibiotics

[ASAP] Sugar-Pirating as an Enabling Platform for the Synthesis of 4,6-Dideoxyhexoses

An efficient divergent synthetic strategy that leverages the natural product spectinomycin to access uniquely functionalized monosaccharides is described. Stereoselective 2′- and 3′-reduction of key spectinomycin-derived intermediates enabled facile access to all eight possible 2,3-stereoisomers of 4,6-dideoxyhexoses as well as representative 3,4,6-trideoxysugars and 3,4,6-trideoxy-3-aminohexoses. In addition, the method was applied to…
bubmag
May 7, 2020