Antibiotics

A large analysis of U.S. urgent care visits from 2018 to 2022 found high rates of inappropriate prescribing for antibiotics, glucocorticoids, and opioids. Visits related to COVID were associated with a lower share of antibiotic prescription fills but a higher share of glucocorticoid fills. "Stewardship programs are needed to reduce…

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Proceedings of the National Academy of Sciences, Volume 122, Issue 29, July 2025. SignificanceAcetylation is a modification of protein N termini, lysine residues, antibiotics, and lipids. Many of the enzymes that promote acetylation belong to the GCN5-related N-acetyltransferase (GNAT) family of proteins.Mycobacterium marinumis a ...Read More

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To identify new antimicrobial candidates, scientists at the University of Pennsylvania mined global venomics datasets using a deep-learning system called APEX. Guan et al. demonstrate that venoms are a rich source of previously hidden antimicrobial scaffolds, and that integrating large-scale computational mining with experimental validation can accelerate the discovery of…

Earlier research raised concerns about antibiotic use during the first trimester of pregnancy and risk for congenital malformations. In this study, the risk of malformation was higher for infants exposed to TMP-SMX versus β-lactam antibiotics. Findings support ACOG's recommendation to avoid TMP-SMX during the first trimester but not ACOG's caution…

Extended oral antibiotic prophylaxis eliminated UTIs after robot-assisted radical cystectomy procedures. Prophylactic antibiotics reduced overall infections by two-thirds and saved $9,000 per patient. Study limitations included small sample size, lack of blinding, and unknown resistance. The risk of infection, especially urinary tract infection (UTI), after robot-assisted radical cystectomy (RARC) almost…

Proceedings of the National Academy of Sciences, Volume 122, Issue 28, July 2025. SignificanceThe bacterial wall is composed of peptidoglycan (PG) and distinguishes bacteria from eukaryotes. Hence, PG synthesis and remodeling are of special interest for the development of antibiotics. Bacterial division represents the most challenging ...Read More

TOPLINE: In a large cohort, long-acting lipoglycopeptides (laLGPs) demonstrated comparable effectiveness to standard-of-care antibiotics for step-down treatment of serious Gram-positive bacterial infections in both individuals who used drugs and those who did not. METHODOLOGY: Standard antibiotic therapy for serious bacterial infections can be challenging due to stigma and logistical barriers…