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A protective role for APP in nuclear waste clearance via lysosomal exocytosis Cursor

A protective role for APP in nuclear waste clearance via lysosomal exocytosis

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceResearch on Alzheimer’s disease (AD) has largely focused on amyloid-β, a fragment of the amyloid precursor protein (APP). However, the physiological functions of APP remain poorly understood. Here, we show that APP protects cells by clearing ...Read…
bubmag
June 11, 2026
“Even dry and lost places can flourish with a little care”: Waterful is a gentle, beautiful puzzler about drawing rivers that makes me yearn for something overwhelming Cursor

“Even dry and lost places can flourish with a little care”: Waterful is a gentle, beautiful puzzler about drawing rivers that makes me yearn for something overwhelming

Image credit: Lenja Kaufmann Waterful is that most appropriate and disquieting of things, a "nature-builder". It's a soft and colourful chillout game in which you cut rivers through procedurally generated landscapes with a cursor, drawing from a limited supply of water that is topped up by connecting springs. Importantly, and…
bubmag
June 10, 2026
In 1649, religious liberty was new. A Maryland law helped embed it in America’s founding. Cursor

In 1649, religious liberty was new. A Maryland law helped embed it in America’s founding.

When the Second Continental Congress declared independence from the British crown on July 4, 1776, it would be another 15 years before the Founding Fathers adopted a constitution that enshrined the “free exercise” of religion. But the yearning for that ideal – and the American distaste for established churches –…
bubmag
June 8, 2026
Token prices fell 98%. Enterprise AI bills tripled. Now the industry wants a standards body to explain why. Cursor

Token prices fell 98%. Enterprise AI bills tripled. Now the industry wants a standards body to explain why.

TL;DR Enterprise AI bills are tripling despite a 98% drop in per-token prices, as agentic tools drive consumption 18.6x higher per developer. The Linux Foundation is launching the Tokenomics Foundation to bring cost discipline to AI spending. Uber blew through its entire 2026 AI coding budget by April. Microsoft revoked its developers’ Claude…
bubmag
June 5, 2026
Marasuchus Was Built for Speed — and 5 Other Facts About an Ancient Dinosaur Relative Cursor

Marasuchus Was Built for Speed — and 5 Other Facts About an Ancient Dinosaur Relative

Marasuchus is a precursor to dinosaurs, one of its closest relatives from the genus Dinosauriform Archosaur. It belongs to the same reptilian family tree as dinosaurs, birds, and pterosaurs, the flying reptiles from the Age of Dinosaurs. This close relative of the mega-dinosaurs that would come next was tiny and…
bubmag
May 29, 2026
Base Launches MCP Gateway Letting Claude and ChatGPT Execute Onchain DeFi Actions Cursor

Base Launches MCP Gateway Letting Claude and ChatGPT Execute Onchain DeFi Actions

Base, the Coinbase-incubated Ethereum layer two ( L2) network, launched Base MCP on Tuesday, a Model Context Protocol gateway that connects artificial intelligence (AI) agents directly to users’ Base Accounts for onchain transactions. Key Takeaways Base launched Base MCP on May 26, 2026, letting AI agents like Claude execute onchain…
bubmag
May 26, 2026