Category

Antibiotics

New technique allows for identification of potential drugs to fight resistant bacteria Antibiotics

New technique allows for identification of potential drugs to fight resistant bacteria

Researchers from the Miami University in Ohio have optimized a new technique that will allow scientists to evaluate how potential inhibitors work on antibiotic-resistant bacteria. This technique, called native state mass spectrometry, provides a quick way for scientists to identify the best candidates for effective clinical drugs, particularly in cases…
bubmag
June 20, 2021
Giving antibiotics an assist Antibiotics

Giving antibiotics an assist

SummaryAntimicrobial resistance (AMR) is the silent pandemic. It has been steadily increasing over many years and threatens to halt the practice of modern medicine. By 2050, the annual number of worldwide deaths due to AMR will be ∼10 million, with an estimated economic impact of 100 trillion USD (1). The…
bubmag
June 10, 2021
Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance Antibiotics

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance

Turning down tolerancePersister cells, which are found in abundance in biofilms, adopt a quiescent state and survive antimicrobial treatments, seeding disease recurrence and incubating new resistance mutations. Building on work implicating the reactive small-molecule hydrogen sulfide in bacterial defense against antibiotics, Shatalin et al. conducted a structure-based screen for inhibitors…
bubmag
June 10, 2021
New defence against superbugs Antibiotics

New defence against superbugs

IMAGE: Dr Bart Eijkelkamp, left, and researchers Felice Adams and Maoge Zang at the Bacterial Host Adaptation Research Laboratory at Flinders University, South Australia view more  Credit: Flinders University For the first time, Australian scientists have confirmed a link between the role of regular fish oil to break down the ability…
bubmag
June 9, 2021
Surveillance and One Health in food production key to halting antimicrobial resistance Antibiotics

Surveillance and One Health in food production key to halting antimicrobial resistance

Antimicrobial agents, such as antibiotics, are essential to treating many human and animal infections and diseases. Their overuse and misuse, however, has led to the development of antimicrobial resistance (AMR), meaning that a drug, such as an antibiotic, might no longer be effective in treating the infection. Without urgent action,…
bubmag
June 7, 2021